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This is the problem I would most like to see solved in ASDF.
(defsystem "foo-test" :defsystem-depends-on ("fiveam") :depends-on ("foo") :class "fiveam-asdf:fiveam-tester-system" :components (("some-system:its-component-class" "myfile" ...) ...) ...)
This has been working since 2.31.4.
IIRC, it was Stelian who prodded me to get D-D-O working properly.
I try to use as many ASDF features as possible and useful, and I think that you can point to iolib.asd as the golden example of current best practices. And yes, I had some issues with D-D-O and Fare fixed them.