Hi!
Looking for a right place for your "SetHandler lisp-handler"?
It isn't restricted to <Location ...>. See http://httpd.apache.org/docs/sections.html
Think about mod_lisp-pages with the extension .mlp:
<Files *.mlp> SetHandler lisp-handler </Files>
Path must exist. When you access http://some.server.test/foo/bar.mlp directory "foo" must exist.
Regards, Stefan